eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0019204|hepatocellular carcinoma |
| Sentences | 7 |
| PubMedID- 23113099 | The mutation in p53 tumor suppressor gene in patients with hepatocellular carcinoma who have been in aflatoxin exposure has been proved. |
| PubMedID- 21745313 | Hepatic aflatoxin b1-dna adducts and tp53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin b1 in southern japan. |
| PubMedID- 20306157 | The prevalence of the mutation in codon 249 of the p53 gene in patients with hepatocellular carcinoma (hcc) in turkey. |
| PubMedID- 22371770 | The objective of this work is: to clarify the relation between the selective mutation resulting in a serine substitution at codon 249 in exon 7 of the p53 gene among patients with hepatocellular carcinomas and patients with cirrhosis, occurring in populations with viral hepatitis b or c infections in egypt; and also to investigate whether polymorphism in the heat shock protein 70 (hsp70) gene has any bearing on individual susceptibility to the development of hcc. |
| PubMedID- 23886144 | Hepatitis b virus genetic variation and tp53 r249s mutation in patients with hepatocellular carcinoma in thailand. |
| PubMedID- 26341700 | Evaluation of ctnnb1 and tp53 variability in patients with hepatocellular carcinoma and occult hepatitis b virus infection. |
| PubMedID- 25111876 | (p53: mut p53), n2-a (neuro-2a cells, mouse neural cells), the brain being a possible target organ in rodents and hepg2 cells (human hepatocellular carcinoma) with functional p53 gene. |
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